We have the opportunity to stop Dent disease from affecting future generations.
Mission Statement: To find a cure for Dent disease by raising funds to support research, promote communication between patients and their families and to raise awareness within the medical community worldwide.
Jennifer Meyer, RN
Steven J. Scheinman M.D.
Chair - Medical/Scientific Advisory Board
History of Dent Disease
A History of Dent Disease
Written by Dr. Anthony Norden
His personal account of his work with Prof. Wrong, and the countless other doctors and scientists who “discovered” and advanced clinical knowledge of Dent disease.
Professor Charles Dent and his colleague Max Friedman publish a paper describing two unrelated boys with an unusual type of rickets, at this time it was not recognized that the disease was hereditary.
The disorder was fully described by Professor Oliver Wrong and colleagues in 1990. Professor Wrong named it after his late colleague Dr. Dent and recognized that the disease was X-linked and hereditary.
Professors Rajesh Thakker, Ian Craig, Thomas Jentsch, Steven Scheinman, Takashi Igarashi, Alessandra Bolino, Marcella Devoto, Oliver Wrong and colleagues identify the gene mutation in the Chloride Ion Channel, CLCN5 as the cause of Dent Disease.
Professor Steven Scheinman and colleagues identify a second cause of Dent Disease caused in the OCRL1 gene.
Major contributors to the study of Dent Disease gathered in the United Kingdom.
Major contributors to the study of Dent Disease
Professor Oliver Wrong and Professor Steven Scheinman visit a family of English butchers affected by Dent Disease. Prof. Wrong kept in touch with many of these families long after he retired and they often used to turn to him for advice.