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Mission Statement: To find a cure for Dent disease by raising funds to support research, promote communication between patients and their families and to raise awareness within the medical community worldwide.
History of Dent Disease
A History of Dent Disease
Written by Dr. Anthony Norden
His personal account of his work with Prof. Wrong, and the countless other doctors and scientists who “discovered” and advanced clinical knowledge of Dent disease.
1964
Professor Charles Dent and his colleague Max Friedman publish a paper describing two unrelated boys with an unusual type of rickets, at this time it was not recognized that the disease was hereditary.
Professor Charles Dent
Photo used with permission by Professors Thakker and Scheinman from 2009 Wrong Symposium.
1990
The disorder was fully described by Professor Oliver Wrong and colleagues in 1990. Professor Wrong named it after his late colleague Dr. Dent and recognized that the disease was X-linked and hereditary.
Professor Oliver M. Wrong
Photo used with permission from Michela Wrong
Professor Oliver M. Wrong
Photo taken and used by permission by Michela Wrong
Magdalen College, Oxford. 2010
1996
Professors Rajesh Thakker, Ian Craig, Thomas Jentsch, Steven Scheinman, Takashi Igarashi, Alessandra Bolino, Marcella Devoto, Oliver Wrong and colleagues identify the gene mutation in the Chloride Ion Channel, CLCN5 as the cause of Dent Disease.
Professor Rajesh Thakker
Photo used with permission from Thakker
2005
Professor Steven Scheinman and colleagues identify a second cause of Dent Disease caused in the OCRL1 gene.
Professor Steven Scheinman
Photo used with permission from Scheinman
2009
London Meeting
Major contributors to the study of Dent Disease gathered in the United Kingdom.
(from left to right): Professors Rajesh Thakker, Oliver Wrong, Steven Scheinman, Thomas Jentsch, Terry Feest, Dr. Anthony Norden.
Photo used with permission from all participants
Major contributors to the study of Dent Disease
Professor Takashi Igarashi
Photo used with permission from Igarashi
Dr. Anthony Norden
Dr. Norden and Professor Wrong were colleagues and close research collaborators.
Photo used with permission from Norden
Professor Robert Unwin
Professor Unwin and Professor Wrong were colleagues and close research collaborators.
Photo used with permission from Unwin
Professor Oliver Wrong and Professor Steven Scheinman visit a family of English butchers affected by Dent Disease. Prof. Wrong kept in touch with many of these families long after he retired and they often used to turn to him for advice.
Photo used with permission by Professor Steven Scheinman.
